Pank2 Gene Summary [Rat]
Predicted to enable pantothenate kinase activity. Predicted to be involved in angiogenesis; coenzyme A biosynthetic process; and regulation of lipid metabolic process. Predicted to act upstream of or within several processes, including aerobic respiration; regulation of mitochondrial membrane potential; and spermatid development. Predicted to be located in mitochondrion. Predicted to be active in cytosol; mitochondrial intermembrane space; and nucleus. Human ortholog(s) of this gene implicated in pantothenate kinase-associated neurodegeneration. Orthologous to human PANK2 (pantothenate kinase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pank2 |
| Official Name | pantothenate kinase 2 [Source:RGD Symbol;Acc:1305169] |
| Ensembl ID | ENSRNOG00000025286 |
| Bio databases IDs | |
| Aliases | pantothenate kinase 2 |
| Synonyms | 4933409I19Rik, AI642621, C20orf48, HARP, hPanK2, HSS, NBIA1, PANK2 isoform 1, pantothenate kinase 2, PKAN |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pank2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Fumble
- pantothenate kinase
- pantothenate kinase, eukaryotic/staphyloccocal type
- protein binding
- ASKHA_ATPase-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- polycystic ovary syndrome
- myelodysplastic syndrome
- hepatic steatosis
- dystonia
- retinal dystrophy
- Hallervorden-Spatz disease
- obesity
regulated by
- INS
- acetyl-coenzyme A
- palmitoyl-coenzyme A
- malonyl-coenzyme A
- EFNA1
- coenzyme A
- MK2206
regulates
- fatty acid
- NADH
- triacylglycerol
- ketone
- coenzyme A
- 3-hydroxybutyric acid
- ketone body
- D-pantothenic acid
- N-((R)-pantothenoyl)-L-cysteine
- pantetheine
role in cell
- phosphorylation in
- development
- organization
- respiration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- cytosol
- mitochondrial intermembrane space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pank2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of mitochondrial membrane potential
- spermatid development
- angiogenesis
- pantothenate metabolic process
- coenzyme A biosynthetic process
- phosphorylation
- aerobic respiration
- regulation of triglyceride metabolic process
- mitochondrion organization
- regulation of fatty acid metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrial intermembrane space
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- pantothenate kinase activity