Ywhaq Gene Summary [Rat]
Enables 14-3-3 protein binding activity and transmembrane transporter binding activity. Involved in negative regulation of monoatomic ion transmembrane transport. Part of protein-containing complex. Is active in synapse. Orthologous to human YWHAQ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ywhaq |
| Official Name | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta [Source:RGD Symbol;Acc:3979] |
| Ensembl ID | ENSRNOG00000051650 |
| Bio databases IDs | |
| Aliases | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta |
| Synonyms | 14-3-3, 14-3-3 protein theta, 14-3-3 protein θ, 14-3-3t, 14-3-3 Tau, 14-3-3 tau/theta, 14-3-3 tau/θ, 14-3-3 theta, 14-3-3 θ, 1C5, 2700028P07Rik, HS1, LOC100503129, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein θ, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, θ |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ywhaq often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- dimerization domain
- 14-3-3 domain
- pseudosubstrate domain
- alpha helix
- ion channel binding
- 14-3-3 protein
- protein domain specific binding
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the Ywhaq gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- prostate cancer
- astrocytoma
- glioma formation
- psoriasis
- breast carcinoma
- preeclampsia
role in cell
- expression in
- apoptosis
- growth
- degradation in
- differentiation
- autophagy by
- invasion by
- endocytosis by
- transcription in
- oligomerization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- apical ectoplasmic specialization
- Nucleus
- cytosol
- synaptic vesicles
- growth cone
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ywhaq gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein targeting
- negative regulation of transcription, DNA-dependent
- small GTPase mediated signal transduction
- signal transduction
- protein localization
- substantia nigra development
- negative regulation of ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- focal adhesion
- cytoplasm
- membrane
- cytosol
- macromolecular complex
- synapse
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein domain specific binding
- protein binding
- ion channel binding
- 14-3-3 protein binding