Disp3 Gene Summary [Rat]
Predicted to be involved in negative regulation of neuron differentiation; positive regulation of lipid metabolic process; and positive regulation of neural precursor cell proliferation. Predicted to be located in membrane. Predicted to be active in cytoplasm. Orthologous to human DISP3 (dispatched RND transporter family member 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Disp3 |
| Official Name | dispatched RND transporter family member 3 [Source:RGD Symbol;Acc:1305820] |
| Ensembl ID | ENSRNOG00000026447 |
| Bio databases IDs | |
| Aliases | dispatched RND transporter family member 3 |
| Synonyms | dispatched RND transporter family member 3, G630052C06Rik, KIAA1337, PTCHD2, RGD1305820, RNDEu-2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Disp3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sterol-sensing domain of SREBP cleavage-activation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Disp3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell differentiation
- negative regulation of neuron differentiation
- cholesterol metabolic process
- positive regulation of neural precursor cell proliferation
- smoothened signaling pathway
- positive regulation of lipid metabolic process
- cholesterol homeostasis
- regulation of lipid transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytoplasmic vesicle membrane
- nuclear membrane
- cytoplasm
- membrane
- endoplasmic reticulum