Rasgrp2 Gene Summary [Rat]
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction; cellular response to calcium ion; and positive regulation of GTPase activity. Predicted to be located in cytosol. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in platelet-type bleeding disorder 18. Orthologous to human RASGRP2 (RAS guanyl releasing protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rasgrp2 |
| Official Name | RAS guanyl releasing protein 2 [Source:RGD Symbol;Acc:1311630] |
| Ensembl ID | ENSRNOG00000021098 |
| Bio databases IDs | |
| Aliases | RAS guanyl releasing protein 2 |
| Synonyms | Caldaggef1, CALDAG-GEFI, CDC25L, LOC381240, RAS guanyl releasing protein 2, RAS, guanyl releasing protein 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rasgrp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-Hand
- Ras exchanger motif
- EF-hand, calcium binding motif
- lipid binding
- EF-hand domain pair
- nuclear localization sequence
- calcium ion binding
- EFh
- Cdc25 domain
- RasGEF
- EF-hand domain
- protein kinase C conserved region 1 (C1 domain) superfamily
- guanyl-nucleotide exchange factor
- EF hand
- zinc finger domain
- REM
Pathways
Biological processes and signaling networks where the Rasgrp2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- platelet-type bleeding disorder type 18
- Huntington disease
- gastrointestinal hemorrhage
- menorrhagia
- epistaxis
- bleeding
- leukocyte adhesion deficiency type I
- essential thrombocythemia
role in cell
- growth
- migration
- activation in
- aggregation
- function
- cell spreading
- adhesion
- cytotoxicity
- response by
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rasgrp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to calcium ion
- regulation of cell growth
- signal transduction
- Ras protein signal transduction
- positive regulation of GTPase activity
Cellular Component
Where in the cell the gene product is active
- cytosol
- ruffle membrane
- synapse
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- calcium ion binding
- guanyl-nucleotide exchange factor activity
- diacylglycerol binding
- lipid binding