Cndp1 Gene Summary [Rat]
Predicted to enable dipeptidase activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within regulation of protein metabolic process. Predicted to be located in extracellular region. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in glomerulonephritis. Orthologous to human CNDP1 (carnosine dipeptidase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cndp1 |
| Official Name | carnosine dipeptidase 1 [Source:RGD Symbol;Acc:1359493] |
| Ensembl ID | ENSRNOG00000027739 |
| Bio databases IDs | |
| Aliases | carnosine dipeptidase 1 |
| Synonyms | carnosine dipeptidase 1, CN1, CNDP dipeptidase 1, CPGL2, HsT2308, MGC93742 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cndp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-Ala-His dipeptidase
- Zinc peptidases M18, M20, M28, and M42
- dipeptidase
- Peptidase family M20/M25/M40
- peptidase
- acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- hepatocellular carcinoma
- chronic fatigue syndrome
- diabetes mellitus
- aortic valve calcification
- streptozotocin-induced diabetic nephropathy
regulated by
- ELAVL1
- tunicamycin
- carnosine
- homocarnosine
- dithiothreitol
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- cytosol
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cndp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of protein metabolic process
- proteolysis
Cellular Component
Where in the cell the gene product is active
- cytosol
- extracellular region
Molecular Function
What the gene product does at the molecular level
- carboxypeptidase activity
- metallodipeptidase activity
- metal ion binding
- dipeptidase activity