Usp30 Gene Summary [Rat]
Predicted to enable cysteine-type deubiquitinase activity and cysteine-type endopeptidase activity. Involved in negative regulation of mitophagy. Predicted to be located in mitochondrial outer membrane. Predicted to be active in cytosol and nucleus. Orthologous to human USP30 (ubiquitin specific peptidase 30). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Usp30 |
| Official Name | ubiquitin specific peptidase 30 [Source:RGD Symbol;Acc:1307949] |
| Ensembl ID | ENSRNOG00000028556 |
| Bio databases IDs | |
| Aliases | ubiquitin specific peptidase 30 |
| Synonyms | 6330590F17RIK, D5Ertd483e, ubiquitin specific peptidase 30 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Usp30 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cysteine endopeptidase
- peptidase
- ubiquitin-specific protease
- Ubiquitin carboxyl-terminal hydrolase
- protein binding
- Peptidase_C19
- ubiquitin-like-specific protease
Pathways
Biological processes and signaling networks where the Usp30 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial outer membrane
- peroxisome membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Usp30 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deubiquitination
- protein K11-linked deubiquitination
- proteolysis
- mitochondrial fusion
- macropexophagy
- protein K6-linked deubiquitination
- mitochondrion degradation
Cellular Component
Where in the cell the gene product is active
- peroxisomal membrane
- nucleus
- mitochondrion
- cytosol
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- protein binding
- cysteine-type endopeptidase activity