USP30
USP30 Gene Summary
USP30, a member of the ubiquitin-specific protease family (see USP1, MIM 603478), is a novel mitochondrial deubiquitinating (DUB) enzyme (Nakamura and Hirose, 2008 [PubMed 18287522]).[supplied by OMIM, Dec 2008]
Details
| Type | Protein Coding |
| Official Symbol | USP30 |
| Official Name | ubiquitin specific peptidase 30 [Source:HGNC Symbol;Acc:HGNC:20065] |
| Ensembl ID | ENSG00000135093 |
| Bio databases IDs | |
| Aliases | ubiquitin specific peptidase 30 |
| Synonyms | 6330590F17RIK,D5Ertd483e,ubiquitin specific peptidase 30 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cysteine endopeptidase
- peptidase
- ubiquitin-specific protease
- Ubiquitin carboxyl-terminal hydrolase
- protein binding
- Peptidase_C19
- ubiquitin-like-specific protease
Pathways
Biological processes and signaling networks where the USP30 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- HAX1
- UBB
- OMA1
- CUL3
- CLEC2B
- CANX
- TOMM40
- TOMM22
- UBC
- PVR
disease
- motor dysfunction
regulated by
- methylphenidate
- UMOD
regulates
- SNCA
role in cell
- loss
- respiration in
- mitophagy in
- pexophagy in
- fusion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial outer membrane
- peroxisome membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the USP30 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- protein deubiquitination
- protein K11-linked deubiquitination
- proteolysis
- mitochondrial fusion
- macropexophagy
- protein K6-linked deubiquitination
- mitochondrion degradation
CELLULAR COMPONENT
Where in the cell the gene product is active
- peroxisomal membrane
- nucleus
- mitochondrion
- cytosol
- mitochondrial outer membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- protein binding
- cysteine-type endopeptidase activity