Slc28a2 Gene Summary [Rat]
Enables nucleoside:sodium symporter activity. Involved in protein localization to cell surface and retina homeostasis. Located in coated vesicle; plasma membrane; and vesicle membrane. Orthologous to human SLC28A2 (solute carrier family 28 member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc28a2 |
| Official Name | solute carrier family 28 member 2 [Source:RGD Symbol;Acc:61840] |
| Ensembl ID | ENSRNOG00000028668 |
| Bio databases IDs | |
| Aliases | solute carrier family 28 member 2 |
| Synonyms | BB152493, CNT2, HCNT2, HsT17153, LOC102556085, N1, solute carrier family 28 member 2, SPNT1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc28a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- uridine transporter
- purine transporter
- purine nucleoside transporter
- nucleoside transporter
- Nucleoside recognition
- transmembrane domain
- pyrimidine- and adenine-specific:sodium symporter
- neurotransmitter transporter
- Na+ dependent nucleoside transporter C-terminus
- Na+ dependent nucleoside transporter N-terminus
- transporter
- nucleoside:sodium symporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
regulated by
- insulin
- 5-N-ethylcarboxamido adenosine
- (R)-(-)-phenylisopropyl adenosine
- K ATP channel
- N6-cyclopentyladenosine
- D-glucose
- RSC1A1
- ADORA1
regulates
- CASP3
- inosine
- purine nucleoside
- nucleoside
- fludarabine
- floxuridine
- guanosine
- didanosine
- cladribine
- 5-fluorouridine
role in cell
- transport in
- absorption in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- apicolateral membrane
- intracellular structures
- cellular membrane
- vesicles
- vesicle membrane
- basolateral membrane
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc28a2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- uridine transport
- purine nucleoside transport
- inosine transport
- nucleobase-containing compound metabolic process
- azole transport
- retina homeostasis
- neurotransmitter transport
- drug transmembrane transport
- pyrimidine-containing compound transmembrane transport
- xenobiotic metabolic process
- adenosine transport
- pyrimidine base transport
Cellular Component
Where in the cell the gene product is active
- apicolateral plasma membrane
- brush border membrane
- vesicle membrane
- membrane
- coated vesicle
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- nucleoside:sodium symporter activity
- pyrimidine- and adenine-specific:sodium symporter activity
- neurotransmitter transporter activity
- uridine transmembrane transporter activity
- purine nucleoside transmembrane transporter activity
- purine base transmembrane transporter activity