Alg12 Gene Summary [Rat]
Predicted to enable dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase. Predicted to be involved in protein N-linked glycosylation. Predicted to act upstream of or within dolichol-linked oligosaccharide biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ig. Orthologous to human ALG12 (ALG12 alpha-1,6-mannosyltransferase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Alg12 |
| Official Name | ALG12, alpha-1,6-mannosyltransferase [Source:RGD Symbol;Acc:1304826] |
| Ensembl ID | ENSRNOG00000004591 |
| Bio databases IDs | |
| Aliases | ALG12, alpha-1,6-mannosyltransferase |
| Synonyms | ALG12 alpha-1,6-mannosyltransferase, ALG12, alpha-1,6-mannosyltransferase, ALG12 α-1,6-mannosyltransferase, ALG12, α-1,6-mannosyltransferase, CDG1G, ECM39, hALG12, PP14673 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Alg12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alpha-1,6-mannosyltransferase
- Alg9-like mannosyltransferase family
- mannosyltransferase
- enzyme
- dolichyl-phosphate-mannose-protein mannosyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hereditary disorder
- congenital disorder of glycosylation type 1g
- schizophrenia
- congenital disorders of glycosylation
regulates
- oligosaccharide-diphosphodolichol
role in cell
- dipeptide repeat protein sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Alg12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein N-linked glycosylation
- protein folding
- dolichol-linked oligosaccharide biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- mannosyltransferase activity
- dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity
- alpha-1,6-mannosyltransferase activity