Alpi Gene Summary [Rat]
Enables alkaline phosphatase activity; metal ion binding activity; and protein homodimerization activity. Involved in dephosphorylation. Located in external side of plasma membrane. Human ortholog(s) of this gene implicated in inflammatory bowel disease. Orthologous to several human genes including ALPI (alkaline phosphatase, intestinal). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Alpi |
| Official Name | alkaline phosphatase, intestinal [Source:RGD Symbol;Acc:2099] |
| Ensembl ID | ENSRNOG00000030020 |
| Bio databases IDs | |
| Aliases | alkaline phosphatase, intestinal |
| Synonyms | alkaline phosphatase, intestinal, Alp1, Iap1, S51097 |
| Species | Rat, Rattus norvegicus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Alpi often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alkaline phosphatases and sulfatases
- alkaline phosphatase
- Alkaline phosphatase homologues
- protease binding
- zinc ion binding
- phosphatase
- protein homodimerization
- protein binding
- magnesium ion binding
Pathways
Biological processes and signaling networks where the Alpi gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
regulated by
- L-triiodothyronine
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane extracellular face