Six6os1 Gene Summary [Rat]
Predicted to be involved in meiosis I; oogenesis; and spermatogenesis. Predicted to be located in chromosome. Predicted to be active in central element. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 18 and spermatogenic failure 52. Orthologous to human C14orf39 (chromosome 14 open reading frame 39). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Six6os1 |
| Official Name | Six6 opposite strand transcript 1 [Source:RGD Symbol;Acc:1559456] |
| Ensembl ID | ENSRNOG00000031655 |
| Bio databases IDs | |
| Aliases | Six6 opposite strand transcript 1 |
| Synonyms | 4921504I02Rik, 4930447C04Rik, A930035O15Rik, chromosome 14 open reading frame 39, POF18, RGD1559456, RIKEN cDNA 4930447C04 gene, Six6as, Six6 opposite strand transcript 1, Six6OS, Six6os1, SPGF52 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Six6os1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Six6 opposite strand transcript 1 family
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- epithelial cancer
- premature ovarian failure type 18
- glaucoma
- refractive error
- spermatogenic failure 52
- open-angle glaucoma
- azoospermia
- hyperopia
- normal tension glaucoma
role in cell
- formation
- synapsis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- chromosome
- synaptonemal complexes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Six6os1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- oogenesis
- meiotic DNA double-strand break processing involved in reciprocal meiotic recombination
- spermatogenesis
- synaptonemal complex assembly
- synapsis
- regulation of sequence-specific DNA binding transcription factor activity
Cellular Component
Where in the cell the gene product is active
- central element
- chromosome
Molecular Function
What the gene product does at the molecular level
- protein binding