Hpgds Gene Summary [Rat]
Predicted to enable several functions, including glutathione transferase activity; metal ion binding activity; and prostaglandin-D synthase activity. Predicted to be involved in glutathione metabolic process and prostaglandin metabolic process. Predicted to act upstream of or within negative regulation of male germ cell proliferation; response to nematode; and response to selenium ion. Predicted to be located in cytosol and nucleoplasm. Orthologous to human HPGDS (hematopoietic prostaglandin D synthase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hpgds |
| Official Name | hematopoietic prostaglandin D synthase [Source:RGD Symbol;Acc:69251] |
| Ensembl ID | ENSRNOG00000006583 |
| Bio databases IDs | |
| Aliases | hematopoietic prostaglandin D synthase |
| Synonyms | Class Sigma GST, Class σ GST, GSTS, GSTS1, GSTS1-1, Gst-ys, haematopoietic prostaglandin D synthase, hematopoietic prostaglandin D synthase, PGD2, PGDS, PROSTAGLANDIN D2 SYNTHASE, haematoPOIETIC, PROSTAGLANDIN D2 SYNTHASE, HEMATOPOIETIC, Ptgds2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hpgds often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glutathione S-transferase, C-terminal domain
- Glutathione S-transferase, N-terminal domain
- C-terminal, alpha helical domain of the Glutathione S-transferase family
- glutathione transferase
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- calcium ion binding
- protein homodimerization
- enzyme
- protein binding
- magnesium ion binding
- prostaglandin-D synthase
Pathways
Biological processes and signaling networks where the Hpgds gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- colitis-associated colon cancer
- muscular dystrophy
- COVID-19
- hyperplasia
- testicular germ cell tumor
- germ cell neoplasia
- head and neck neoplasia
- allergic rhinitis
- astrocytosis
role in cell
- expression in
- proliferation
- apoptosis
- damage
- infiltration by
- Th2 immune response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- perinuclear region
- cellular membrane
- cytosol
- cisternae
- nucleoplasm
- neurites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hpgds gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- locomotory behavior
- signal transduction
- glutathione metabolic process
- prostaglandin biosynthetic process
- negative regulation of male germ cell proliferation
- prostaglandin metabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- prostaglandin-D synthase activity
- protein binding
- protein homodimerization activity
- calcium ion binding
- glutathione transferase activity