C14orf39 Gene Summary [Human]
Predicted to be involved in gamete generation and meiosis I. Predicted to be located in chromosome. Predicted to be active in central element. Implicated in primary ovarian insufficiency 18 and spermatogenic failure 52. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | C14orf39 |
| Official Name | chromosome 14 open reading frame 39 [Source:HGNC Symbol;Acc:HGNC:19849] |
| Ensembl ID | ENSG00000179008 |
| Bio databases IDs | |
| Aliases | chromosome 14 open reading frame 39 |
| Synonyms | 4921504I02Rik, 4930447C04Rik, A930035O15Rik, chromosome 14 open reading frame 39, POF18, RGD1559456, RIKEN cDNA 4930447C04 gene, Six6as, Six6 opposite strand transcript 1, Six6OS, Six6os1, SPGF52 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human C14orf39 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Six6 opposite strand transcript 1 family
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- chromosome
- synaptonemal complexes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human C14orf39 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- oogenesis
- meiotic DNA double-strand break processing involved in reciprocal meiotic recombination
- spermatogenesis
- synaptonemal complex assembly
- synapsis
- regulation of sequence-specific DNA binding transcription factor activity
Cellular Component
Where in the cell the gene product is active
- central element
- chromosome
Molecular Function
What the gene product does at the molecular level
- protein binding