Cyp2d4

Enables arachidonate monooxygenase activity and progesterone 21-hydroxylase activity. Involved in several processes, including carboxylic acid metabolic process; dopamine biosynthetic process; and response to toluene. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Biomarker of traumatic brain injury. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hepatitis; extrapyramidal and movement disease; head and neck squamous cell carcinoma; leukemia (multiple); and major depressive disorder. Orthologous to several human genes including CYP2D6 (cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene)). [provided by Alliance of Genome Resources, Apr 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cyp2d4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Cyp2d4 gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.