Dand5 Gene Summary [Rat]
This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns left/right body asymmetry. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | Dand5 |
| Official Name | DAN domain BMP antagonist family member 5 [Source:RGD Symbol;Acc:1590249] |
| Ensembl ID | ENSRNOG00000033368 |
| Bio databases IDs | |
| Aliases | DAN domain BMP antagonist family member 5 |
| Synonyms | CER2, CERL2, Cerr2, CKTSF1B3, COCO, CRL2, DAN domain BMP antagonist family member 5, DAN domain family member 5, BMP antagonist, DANTE, Dte, GREM3, LOC684634, SP1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dand5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycoprotein hormone beta chain homologues
- morphogen
- protein binding
- DAN domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dand5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- determination of heart left/right asymmetry
- sequestering of nodal from receptor via nodal binding
- ventricular septum development
- sequestering of BMP in extracellular matrix
- signal transduction involved in regulation of gene expression
- atrial septum development
- determination of left/right asymmetry in lateral mesoderm
- negative regulation of nodal signaling pathway
- determination of left/right symmetry
- nodal signaling pathway
- negative regulation of BMP signaling pathway
- negative regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- morphogen activity