Dand5 Gene Summary [Mouse]
Enables morphogen activity. Involved in determination of left/right asymmetry in lateral mesoderm; heart development; and negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Acts upstream of or within determination of left/right symmetry and negative regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in embryo; gut; node; and primitive streak. Human ortholog(s) of this gene implicated in visceral heterotaxy 13. Orthologous to human DAND5 (DAN domain BMP antagonist family member 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dand5 |
| Official Name | DAN domain family member 5, BMP antagonist [Source:MGI Symbol;Acc:MGI:1344365] |
| Ensembl ID | ENSMUSG00000053226 |
| Bio databases IDs | |
| Aliases | DAN domain family member 5, BMP antagonist |
| Synonyms | CER2, CERL2, Cerr2, CKTSF1B3, COCO, CRL2, DAN domain BMP antagonist family member 5, DAN domain family member 5, BMP antagonist, DANTE, Dte, GREM3, LOC684634, SP1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dand5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycoprotein hormone beta chain homologues
- morphogen
- protein binding
- DAN domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dand5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- determination of heart left/right asymmetry
- sequestering of nodal from receptor via nodal binding
- ventricular septum development
- sequestering of BMP in extracellular matrix
- signal transduction involved in regulation of gene expression
- atrial septum development
- determination of left/right asymmetry in lateral mesoderm
- negative regulation of nodal signaling pathway
- determination of left/right symmetry
- nodal signaling pathway
- negative regulation of BMP signaling pathway
- negative regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- morphogen activity