Arhgap8 Gene Summary [Rat]
Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of endocytic recycling; positive regulation of ERK1 and ERK2 cascade; and small GTPase-mediated signal transduction. Predicted to act upstream of or within actin cytoskeleton organization and positive regulation of cell migration. Predicted to be active in cytoplasm. Orthologous to human ARHGAP8 (Rho GTPase activating protein 8). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arhgap8 |
| Official Name | Rho GTPase activating protein 8 [Source:RGD Symbol;Acc:1303143] |
| Ensembl ID | ENSRNOG00000033570 |
| Bio databases IDs | |
| Aliases | Rho GTPase activating protein 8 |
| Synonyms | 3110043J09RIK, BPGAP1, PP610, Rho GTPase activating protein 8 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Arhgap8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- Domain in homologues of a S
- BCH domain
- Divergent CRAL/TRIO domain
- CRAL/TRIO domain
- GTPase activator
- protein binding
- GTPase Activating Protein domain
- GTPase-activator protein for Rho-like GTPases
- RhoGAP
- proline rich domain
Pathways
Biological processes and signaling networks where the Arhgap8 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver neoplasia
- epithelial neoplasia
- epithelial cancer
- cancer
- breast cancer
- cleft lip
- cholangiocarcinoma cancer
- liver cancer
- bile duct cancer
- biliary tract cancer
role in cell
- migration
- binding in
- formation
- cell spreading
- polarization
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell periphery
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Arhgap8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- small GTPase mediated signal transduction
- regulation of small GTPase mediated signal transduction
- positive regulation of ERK1 and ERK2 cascade
- negative regulation of endocytic recycling
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activator activity