Nr3c2 Gene Summary [Rat]
Enables several functions, including DNA binding activity; histone acetyltransferase binding activity; and transcription coactivator binding activity. Involved in several processes, including nuclear receptor-mediated corticosteroid signaling pathway; positive regulation of transcription by RNA polymerase II; and response to mineralocorticoid. Located in cytoplasm and nucleus. Is active in glutamatergic synapse; postsynaptic density, intracellular component; and presynaptic active zone cytoplasmic component. Used to study alcohol use disorder; morphine dependence; and polycystic ovary syndrome. Biomarker of alcohol dependence; fetal alcohol spectrum disorder; obesity; and steatotic liver disease. Human ortholog(s) of this gene implicated in autosomal dominant pseudohypoaldosteronism type 1; opioid abuse; and pseudohypoaldosteronism. Orthologous to human NR3C2 (nuclear receptor subfamily 3 group C member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nr3c2 |
| Official Name | nuclear receptor subfamily 3, group C, member 2 [Source:RGD Symbol;Acc:3094] |
| Ensembl ID | ENSRNOG00000034007 |
| Bio databases IDs | |
| Aliases | nuclear receptor subfamily 3, group C, member 2 |
| Synonyms | MCR, Mineralocorticoid Receptor, MLR, MR, NR3C2VIT, nuclear receptor subfamily 3 group C member 2, nuclear receptor subfamily 3, group C, member 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nr3c2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sumoylation motif
- steroid hormone receptor
- DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
- transcription factor binding
- inhibitory domain
- AF-2 transcription activation domain
- identical protein binding
- TATA-binding protein binding
- hormone binding domain
- nuclear receptor ligand binding domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- AF-1 domain
- ligand-binding domain
- ligand-dependent nuclear receptor
- histone acetyltransferase binding
- DNA binding domain
- protein binding
- sequence-specific DNA binding
- steroid binding
- binding protein
- double-stranded DNA binding
- hinge domain
- zinc finger domain
- AF-1a domain
- Ligand-binding domain of nuclear hormone receptor
- transcription factor activity
- AF-1b domain
Pathways
Biological processes and signaling networks where the Nr3c2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- essential hypertension
- acute decompensated heart failure
- congestive heart failure
- non-insulin-dependent diabetes mellitus
- infection
- breast cancer
- major depression
- atrial fibrillation
- post-traumatic stress disorder
regulated by
- progesterone
- PKA
- glucocorticoid
- hydrocortisone
- AGT
- beta-estradiol
- aldosterone
- nicotine
- spironolactone
- fluoxetine
role in cell
- proliferation
- function
- synaptic transmission
- binding in
- signaling in
- expression in
- activation in
- phosphorylation in
- quantity
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- soluble fraction
- glutaminergic synapse
- organelle
- Cytoplasm
- cell surface
- cytosol
- nucleoplasm
- synapse
- chromatin
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nr3c2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- intracellular steroid hormone receptor signaling pathway
- signal transduction
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- cytosol
- receptor complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
- estrogen response element binding
- steroid hormone receptor activity
- TBP-class protein binding
- steroid binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity