Ncoa6 Gene Summary [Rat]
Enables several functions, including identical protein binding activity; nuclear receptor binding activity; and peroxisome proliferator activated receptor binding activity. Involved in ovarian follicle development; positive regulation of insulin secretion involved in cellular response to glucose stimulus; and positive regulation of transcription by RNA polymerase II. Part of protein-containing complex. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in breast cancer; colon cancer; and lung cancer. Orthologous to human NCOA6 (nuclear receptor coactivator 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ncoa6 |
| Official Name | nuclear receptor coactivator 6 [Source:RGD Symbol;Acc:620111] |
| Ensembl ID | ENSRNOG00000018288 |
| Bio databases IDs | |
| Aliases | nuclear receptor coactivator 6 |
| Synonyms | AIB3, ASC-2, Erap140, mKIAA0181, Ncoa7, NRC, nuclear receptor coactivator 6, PRIP, RAP250, TRBP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ncoa6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- AD2 domain
- Ser-Thr-Leu rich region
- transcription regulator
- ligand-dependent nuclear receptor interactor
- LXXLL motif
- nuclear receptor domain
- transcription co-activator
- retinoic acid receptor binding
- protein binding activity, bridging
- vitamin D receptor binding
- IXXIM motif
- enzyme binding
- chromatin binding
- protein domain specific binding
- estrogen receptor binding
- protein binding
- thyroid hormone receptor binding
- identical protein binding
- androgen receptor binding domain
- autonomous transactivation domain
- peroxisome proliferator activated receptor binding
- Putative nucleic acid-binding region
- retinoid X receptor binding
Pathways
Biological processes and signaling networks where the Ncoa6 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- venous thromboembolism
- melanoma
- melanoma cancer
- coronary artery disease
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- non-melanoma skin cancer
role in cell
- activation in
- expression in
- quantity
- proliferation
- apoptosis
- differentiation
- growth
- migration
- formation
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Mitochondria
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ncoa6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart development
- positive regulation of transcription, DNA-dependent
- myeloid cell differentiation
- transcription initiation, DNA-dependent
- brain development
- positive regulation of transcription from RNA polymerase II promoter
- response to DNA damage stimulus
- response to hormone stimulus
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- histone methyltransferase complex
- intracellular membrane-bounded organelle
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity
- ligand-dependent nuclear receptor transcription coactivator activity
- estrogen receptor binding
- chromatin binding
- retinoid X receptor binding
- thyroid hormone receptor binding
- enzyme binding