Taf2 Gene Summary [Rat]
Predicted to enable chromatin binding activity and transcription cis-regulatory region binding activity. Predicted to contribute to RNA polymerase II general transcription initiation factor activity. Involved in response to paraquat. Predicted to be located in nucleus. Predicted to be part of transcription factor TFIID complex and transcription factor TFTC complex. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 40. Orthologous to human TAF2 (TATA-box binding protein associated factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Taf2 |
| Official Name | TATA-box binding protein associated factor 2 [Source:RGD Symbol;Acc:621487] |
| Ensembl ID | ENSRNOG00000034022 |
| Bio databases IDs | |
| Aliases | TATA-box binding protein associated factor 2 |
| Synonyms | 4732460C16RIK, AI425886, CIF150, MRT40, TAF2B, TAFII-150, TAFIIB, TATA-box binding protein associated factor 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Taf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- double-stranded DNA binding
- nucleic acid binding
- protein binding
- peptidase GluZincin family
- sequence-specific DNA binding
Pathways
Biological processes and signaling networks where the Taf2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Taf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA transcription from RNA polymerase II promoter
- RNA polymerase II transcriptional preinitiation complex assembly
- G2/M transition of mitotic cell cycle
- positive regulation of transcription, DNA-dependent
- positive regulation of transcription initiation from RNA polymerase II promoter
- regulation of DNA repair
- response to organic cyclic compound
- transcription initiation from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor TFIID complex
- transcription factor TFTC complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- general RNA polymerase II transcription factor activity
- transcription regulatory region sequence-specific DNA binding
- chromatin binding