Mir376b Gene Summary [Rat]
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Details
| Type | Micro RNA |
| Official Symbol | Mir376b |
| Official Name | microRNA 376b [Source:RGD Symbol;Acc:2325421] |
| Ensembl ID | ENSRNOG00000036490 |
| Bio databases IDs | |
| Aliases | microRNA 376b |
| Synonyms | ENSMUSG00002075306, ENSMUSG00002075306.1 microRNA, hsa-miR-368, HSA-MIR-376A, hsa-mir-376a-1, hsa-mir-376a-2, hsa-miR-376b, hsa-miR-376c, MI0006129, MI0006139, microRNA 3595, microRNA 368, microRNA 376a, microRNA 376A1, microRNA 376a-2, microRNA 376b, microRNA 376c, Mir3595, MIR376A, MIR376A1, MIR376A2, miR-376a-3p2, MIR376B, MIR376C, MIRN368, MIRN376A, MIRN376A-1, MIRN376A-2, MIRN376B, MIRN376C, miRNA368, mmu-mir-368, mmu-miR-376, mmu-miR-376a, mmu-miR-376b, mmu-miR-376c, rno-mir-3595, rno-mir-368, rno-miR-376a, rno-miR-376b, rno-miR-376c |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mir376b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- translation repressor
- mRNA binding
- microRNA
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Duchenne muscular dystrophy
- idiopathic pulmonary fibrosis
- colorectal cancer
- breast cancer
- nemaline myopathy
- limb-girdle muscular dystrophy type 2B
- experimental autoimmune encephalomyelitis
- LMNA-related congenital muscular dystrophy
- insulinoma
role in cell
- proliferation
- differentiation
- expression in
- cell viability
- migration
- invasion by
- response by
- guidance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm