Cisd3 Gene Summary [Rat]
Predicted to enable 2 iron, 2 sulfur cluster binding activity and metal ion binding activity. Predicted to be involved in protein maturation. Predicted to be active in mitochondrion. Orthologous to human CISD3 (CDGSH iron sulfur domain 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cisd3 |
| Official Name | CDGSH iron sulfur domain 3 [Source:RGD Symbol;Acc:1559720] |
| Ensembl ID | ENSRNOG00000036894 |
| Bio databases IDs | |
| Aliases | CDGSH iron sulfur domain 3 |
| Synonyms | CDGSH iron sulfur domain 3, CDGSH iron sulphur domain 3, LOC688169, Mel-13, Miner2, MiNT, RGD1559720 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cisd3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- Iron-binding zinc finger CDGSH type
- metal ion binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- hepatocellular carcinoma
- liver cancer
- prostate cancer
- organismal death
- lymphatic neoplasia
- thymoma
- diffuse large B-cell lymphoma
- B-cell non-Hodgkin disease
regulates
- reactive oxygen species
- lipid
- heavy metal
role in cell
- production in
- ferroptosis
- removal
- homeostasis
- accumulation in
- peroxidation in
- glutaminolysis in
- homeostasis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cisd3 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- 2 iron, 2 sulfur cluster binding