Dlat Gene Summary [Rat]
Enables dihydrolipoyllysine-residue acetyltransferase activity. Involved in pyruvate decarboxylation to acetyl-CoA. Located in mitochondrion. Part of pyruvate dehydrogenase complex. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human DLAT (dihydrolipoamide S-acetyltransferase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dlat |
| Official Name | dihydrolipoamide S-acetyltransferase [Source:RGD Symbol;Acc:619859] |
| Ensembl ID | ENSRNOG00000009994 |
| Bio databases IDs | |
| Aliases | dihydrolipoamide S-acetyltransferase |
| Synonyms | 6332404G05Rik, DIHYDROLIPOAMIDE S-ACETYLTRANSFERASE, DLTA, E2, E2P, PBC, PDC-E2, PDH-E2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dlat often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase
- nucleotide binding
- pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form
- enzyme
- protein binding
- identical protein binding
- e3 binding domain
- Biotinyl_lipoyl_domains
- lipoyl domain
- dihydrolipoamide S-acetyltransferase
- sucB
- 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
- Biotin-requiring enzyme
- acetyltransferase
- aldehyde or oxo group:NAD or NADP oxidoreductase
- pyruvate dehydrogenase
Pathways
Biological processes and signaling networks where the Dlat gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Leigh syndrome
- primary central nervous system lymphoma
- primary cancer
- lymphomagenesis
- central nervous system cancer
- breast cancer
- Alzheimer disease
- deficiency of pyruvate dehydrogenase e2
- non-small cell lung cancer
- organismal death
role in cell
- production in
- apoptosis
- proliferation
- activation in
- glycolytic capacity
- mitochondrial respiration in
- glycolysis in
- glycolytic reserve
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- mitochondrial fraction
- intracellular membrane-bounded organelle
- perinuclear region
- cellular membrane
- Mitochondria
- synaptic membrane
- mitochondrial matrix
- cytoskeletal fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dlat gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- acetyl-CoA biosynthetic process from pyruvate
- tricarboxylic acid cycle
- glucose metabolic process
Cellular Component
Where in the cell the gene product is active
- pyruvate dehydrogenase complex
- mitochondrial matrix
- intracellular membrane-bounded organelle
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- pyruvate dehydrogenase (NAD+) activity
- dihydrolipoyllysine-residue acetyltransferase activity