Abhd12 Gene Summary [Rat]
Predicted to enable lysophospholipase activity; monoacylglycerol lipase activity; and palmitoyl-(protein) hydrolase activity. Predicted to be involved in glycerolipid catabolic process; protein depalmitoylation; and regulation of inflammatory response. Predicted to act upstream of or within adult walking behavior and response to auditory stimulus. Predicted to be located in dendrite cytoplasm and membrane. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in PHARC syndrome. Orthologous to human ABHD12 (abhydrolase domain containing 12, lysophospholipase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Abhd12 |
| Official Name | abhydrolase domain containing 12 [Source:RGD Symbol;Acc:1562570] |
| Ensembl ID | ENSRNOG00000036934 |
| Bio databases IDs | |
| Aliases | abhydrolase domain containing 12 |
| Synonyms | 1500011G07RIK, 6330583M11Rik, ABHD12A, abhydrolase domain containing 12, abhydrolase domain containing 12, lysophospholipase, BEM46L2, C20orf22, dJ965G21.2, hABHD12, PHARC |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Abhd12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Prolyl oligopeptidase family
- lysophospholipase
- Serine aminopeptidase, S33
- Alpha/beta hydrolase family
- acylglycerol lipase
- enzyme
- palmitoyl-(protein) hydrolase
- phospholipase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- retinal dystrophy
- polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract
- organismal death
- Alzheimer disease
- ataxia
- hepatocellular carcinoma
- muscle weakness
- microgliosis
regulated by
- lipopolysaccharide
- IPMK
- hydroxypropyl-beta-cyclodextrin
- Mef cells
- AMPK activator 991
regulates
- 2-arachidonoylglycerol
- monoacylglycerol
- glycerophospholipid
- acylglycerol
- 22:1 lysophosphatidylserine
- 1-oleoyl-lysophosphatidylserine
- 22:0 lysophosphatidylserine
- DLG4
- arachidonic acid
- monolaurin
role in cell
- phagocytosis by
- migration
- proliferation
- activation
- ferroptosis
- size
- sorafenib resistance
- morphology
- clonogenicity
- palmitoylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cellular membrane
- endoplasmic reticulum membrane
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Abhd12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adult walking behavior
- acylglycerol catabolic process
- glycerophospholipid catabolic process
- monoacylglycerol catabolic process
- phospholipid catabolic process
- response to auditory stimulus
- regulation of inflammatory response
- phosphatidylserine catabolic process
- arachidonic acid metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
- membrane
- dendrite cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- lysophospholipase activity
- acylglycerol lipase activity
- palmitoyl-(protein) hydrolase activity
- phospholipase activity