Nceh1 Gene Summary [Rat]
Predicted to enable phosphate ion binding activity and serine hydrolase activity. Predicted to be involved in ether lipid metabolic process. Predicted to act upstream of or within protein dephosphorylation and xenobiotic metabolic process. Predicted to be located in membrane. Orthologous to human NCEH1 (neutral cholesterol ester hydrolase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nceh1 |
| Official Name | neutral cholesterol ester hydrolase 1 [Source:RGD Symbol;Acc:1311104] |
| Ensembl ID | ENSRNOG00000013313 |
| Bio databases IDs | |
| Aliases | neutral cholesterol ester hydrolase 1 |
| Synonyms | AADACL1, B230106I24Rik, CPO-BP, Kiaa1363, NCEH, neutral cholesterol ester hydrolase 1, RGD1311104 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nceh1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alpha/beta hydrolase fold
- sterol esterase
- alpha/beta hydrolases
- serine hydrolase
- enzyme
- phosphate binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- acute myeloid leukemia
- atherosclerosis
- prostate cancer
- prostatic carcinoma
- multiple system atrophy
role in cell
- expression in
- apoptosis
- accumulation in
- function
- splicing in
- hydrolysis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- cellular membrane
- Nucleus
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nceh1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- low-density lipoprotein particle clearance
- xenobiotic metabolic process
- ether lipid metabolic process
- lipid catabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- serine hydrolase activity
- acetylalkylglycerol acetylhydrolase activity
- sterol esterase activity
- phosphate ion binding