Lrp6 Gene Summary [Rat]
Predicted to enable several functions, including Wnt receptor activity; Wnt-protein binding activity; and coreceptor activity. Involved in several processes, including canonical Wnt signaling pathway; positive regulation of cytosolic calcium ion concentration; and response to peptide hormone. Located in neuronal cell body. Human ortholog(s) of this gene implicated in tooth agenesis. Orthologous to human LRP6 (LDL receptor related protein 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lrp6 |
| Official Name | LDL receptor related protein 6 [Source:RGD Symbol;Acc:1304749] |
| Ensembl ID | ENSRNOG00000006338 |
| Bio databases IDs | |
| Aliases | LDL receptor related protein 6 |
| Synonyms | ADCAD2, C030016K15RIK, CD, Gw, LDL receptor related protein 6, LOC100502826, Low-density lipoprotein receptor-related protein 6, ska26, ska<m26Jus>, skax26, STHAG7 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lrp6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Wnt-protein binding
- SMP-30/Gluconolactonase/LRE-like region
- frizzled binding
- kinase inhibitor activity
- Wnt receptor
- NHL repeat unit of beta-propeller proteins
- identical protein binding
- Wnt binding domain
- cytoplasmic domain
- intracellular domain
- LDLa
- toxin transporter
- transmembrane receptor
- Coagulation Factor Xa inhibitory site
- coreceptor
- extracellular domain
- beta propeller
- ectodomain
- protein binding
- receptor binding
- Low-density lipoprotein receptor repeat class B
- EGF-like domain
- PPPSP motif
- protein serine/threonine kinase inhibitor
- transmembrane domain
- protein homodimerization
- low-density lipoprotein receptor
- Low-density lipoprotein-receptor YWTD domain
Pathways
Biological processes and signaling networks where the Lrp6 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Colorectal Cancer Metastasis Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- Gap Junction Signaling
- Molecular Mechanisms of Cancer
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- Alzheimer disease
- fibrosis
- neoplasia
- Burkitt lymphoma
- hepatocellular carcinoma
- hereditary disorder
- liver cancer
- epithelial cancer
- selective tooth agenesis type 7
role in cell
- expression in
- activity
- activation in
- migration
- phosphorylation in
- binding
- proliferation
- tyrosine phosphorylation in
- signaling in
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- Extracellular Space
- perinuclear region
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- caveolae
- endosomal membrane
- early endosomes
- cytoplasmic vesicles
- membrane rafts
- perikaryon
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Lrp6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of smooth muscle cell apoptotic process
- transmembrane transport
- neural crest cell differentiation
- nervous system development
- positive regulation of cell cycle
- synaptic transmission
- endocytosis
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of sequence-specific DNA binding transcription factor activity
- response to peptide hormone stimulus
- elevation of cytosolic calcium ion concentration
- dopaminergic neuron differentiation
- positive regulation of transcription, DNA-dependent
- cellular response to cholesterol
- Wnt receptor signaling pathway
- canonical Wnt receptor signaling pathway
- negative regulation of protein serine/threonine kinase activity
- neural crest formation
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- caveola
- early endosome
- cytoplasmic vesicle
- Golgi apparatus
- endoplasmic reticulum
- synapse
- neuronal cell body
- extracellular region
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- coreceptor activity
- identical protein binding
- frizzled binding
- Wnt-activated receptor activity
- protein binding
- protein homodimerization activity
- kinase inhibitor activity
- low-density lipoprotein receptor activity
- Wnt-protein binding
- toxin transporter activity
- receptor binding