Slco1a1 Gene Summary [Rat]
Enables organic anion transmembrane transporter activity. Involved in organic anion transport and response to testosterone. Located in membrane. Biomarker of Dubin-Johnson syndrome and primary biliary cholangitis. Orthologous to human SLCO1A2 (solute carrier organic anion transporter family member 1A2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slco1a1 |
| Official Name | solute carrier organic anion transporter family, member 1a1 [Source:RGD Symbol;Acc:3700] |
| Ensembl ID | ENSRNOG00000036984 |
| Bio databases IDs | |
| Aliases | solute carrier organic anion transporter family, member 1a1 |
| Synonyms | A530084B21, LOC100360270, Oatp, OATP-1, Oatp1a1, Slc21a1, Slc21a3, Slco1a, solute carrier organic anion transporter family, member 1a1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slco1a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Organic Anion Transporter Polypeptide (OATP) family
- Major Facilitator Superfamily
- sodium-independent organic anion transporter
- organic anion transporter
- KAZAL_FS
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
regulates
- methotrexate
- paclitaxel
- 17beta-estradiol-17-beta-D-glucuronide
- bilirubin
- estrone sulfate
- diaminneplatinum(II)-chlorocholylglycinate
- Bamet-UD2
- taurocholic acid
- bile salt
- gadolinium ethoxybenzyl DTPA
disease
- cholestasis
- alloxan-induced diabetic nephropathy
- proximal tubular toxicity
- streptozotocin-induced diabetic nephropathy
- diabetic nephropathy
- liver neoplasm
- liver neoplasia
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-soluble membrane fractions
- membrane fraction
- Cytoplasm
- cell surface
- cellular membrane
- microsome
- apical membrane
- basolateral membrane
- basal membrane
- brush border