Becn2 Gene Summary [Rat]
Predicted to enable phosphatidylinositol 3-kinase binding activity and protein-macromolecule adaptor activity. Predicted to be involved in cellular response to nitrogen starvation; late endosome to vacuole transport; and macroautophagy. Predicted to act upstream of or within several processes, including G protein-coupled receptor catabolic process; endosome to lysosome transport; and glucose homeostasis. Predicted to be part of phosphatidylinositol 3-kinase complex, class III, type I and phosphatidylinositol 3-kinase complex, class III, type II. Predicted to be active in phagophore assembly site. Orthologous to human BECN2 (beclin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Becn2 |
| Official Name | beclin 2 [Source:RGD Symbol;Acc:1563293] |
| Ensembl ID | ENSRNOG00000038076 |
| Bio databases IDs | |
| Aliases | beclin 2 |
| Synonyms | Beclin 2, BECN1L1, BECN1P1, Gm104, Gm38100, RGD1563293 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Becn2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Apg6 coiled-coil region
- binding protein
- protein binding
- Apg6 BARA domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Becn2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagic vacuole assembly
- autophagy
- late endosome to vacuole transport
- endosome to lysosome transport
- macromitophagy
- cellular response to nitrogen starvation
Cellular Component
Where in the cell the gene product is active
- phosphatidylinositol 3-kinase complex II
- phosphatidylinositol 3-kinase complex I
- pre-autophagosomal structure
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol 3-kinase binding
- protein binding
- protein binding, bridging