Pik3c3 Gene Summary [Rat]
Enables 1-phosphatidylinositol-3-kinase activity. Involved in several processes, including autophagosome assembly; phosphatidylinositol 3-kinase/protein kinase B signal transduction; and response to L-leucine. Predicted to be located in several cellular components, including autolysosome; cytoplasmic vesicle; and midbody. Predicted to be part of phosphatidylinositol 3-kinase complex, class III, type I and phosphatidylinositol 3-kinase complex, class III, type II. Predicted to be active in several cellular components, including GABA-ergic synapse; endosome; and glutamatergic synapse. Orthologous to human PIK3C3 (phosphatidylinositol 3-kinase catalytic subunit type 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pik3c3 |
| Official Name | phosphatidylinositol 3-kinase, catalytic subunit type 3 [Source:RGD Symbol;Acc:620899] |
| Ensembl ID | ENSRNOG00000017840 |
| Bio databases IDs | |
| Aliases | phosphatidylinositol 3-kinase, catalytic subunit type 3 |
| Synonyms | 5330434F23RIK, hVps34, phosphatidylinositol 3-kinase catalytic subunit type 3, phosphatidylinositol 3-kinase, catalytic subunit type 3, PI3KC3, VPS34 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pik3c3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- activation domain
- lipid kinase
- protein kinase
- Phosphatidylinositol 3- and 4-kinase
- coiled-coil domain
- protein binding
- PI3Ka
- kinase
- phosphatidylinositol 3-kinase
- Phosphoinositide 3-kinase, catalytic domain
- Protein Kinases, catalytic domain
- alcohol group acceptor phosphotransferase
- C2 domain
Pathways
Biological processes and signaling networks where the Pik3c3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Apelin Cardiomyocyte Signaling Pathway
- Apelin Pancreas Signaling Pathway
- Clathrin-mediated Endocytosis Signaling
- CNTF Signaling
- CXCR4 Signaling
- Docosahexaenoic Acid (DHA) Signaling
- EGF Signaling
- ErbB Signaling
- ErbB4 Signaling
- Glucocorticoid Receptor Signaling
- Growth Hormone Signaling
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- IL-9 Signaling
- JAK/Stat Signaling
- LPS-stimulated MAPK Signaling
- Mouse Embryonic Stem Cell Pluripotency
- MSP-RON Signaling Pathway
- Neurotrophin/TRK Signaling
- NGF Signaling
- Nitric Oxide Signaling in the Cardiovascular System
- p53 Signaling
- PDGF Signaling
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- Th1 Pathway
- Th2 Pathway
- Thyroid Cancer Signaling
- VEGF Family Ligand-Receptor Interactions
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- metastasis
- anemia
- peripheral T-cell lymphoma
- natural killer/T-cell lymphoma
- weight loss
- growth failure
- metabolic syndrome X
- T-cell non-Hodgkin disease
- natural killer cell neoplasia
role in cell
- expression in
- apoptosis
- growth
- activation in
- size
- quantity
- autophagy in
- proliferation
- cell death
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- postsynaptic region
- endosomes
- axonemes
- midbody
- cytosol
- synapse
- early endosomes
- late endosomes
- multivesicular bodies
- autolysosomes
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pik3c3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein localization to pre-autophagosomal structure
- phosphatidylinositol-3-phosphate biosynthetic process
- protein lipidation
- phosphatidylinositol phosphorylation
- endocytosis
- protein targeting to lysosome
- cellular response to glucose starvation
- cell division
- autophagic vacuole assembly
- phosphatidylinositol-mediated signaling
- autophagy
- early endosome to late endosome transport
- regulation of autophagy
- peroxisome degradation
- regulation of cytokinesis
- regulation of macroautophagy
- macroautophagy
Cellular Component
Where in the cell the gene product is active
- phosphatidylinositol 3-kinase complex II
- phosphatidylinositol 3-kinase complex I
- pre-autophagosomal structure
- phosphatidylinositol 3-kinase complex, class III
- late endosome
- axoneme
- autophagic vacuole
- peroxisome
- endosome
- cytoplasm
- membrane
- phagocytic vesicle membrane
- cytosol
- midbody
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol kinase activity
- ATP binding
- protein binding
- protein kinase activity
- kinase activity
- 1-phosphatidylinositol-3-kinase activity