Gm38100 Gene Summary [Mouse]
Predicted to enable phosphatidylinositol 3-kinase binding activity and protein-macromolecule adaptor activity. Involved in G protein-coupled receptor catabolic process; autophagy; and endosome to lysosome transport. Acts upstream of or within glucose homeostasis. Predicted to be located in cytoplasm. Predicted to be part of phosphatidylinositol 3-kinase complex, class III, type I and phosphatidylinositol 3-kinase complex, class III, type II. Predicted to be active in phagophore assembly site. Is expressed in several structures, including liver; reproductive system; skeletal muscle; stomach; and thymus. Orthologous to human BECN2 (beclin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gm38100 |
| Official Name | predicted gene, 38100 [Source:MGI Symbol;Acc:MGI:5611328] |
| Ensembl ID | ENSMUSG00000104158 |
| Bio databases IDs | |
| Aliases | predicted gene, 38100 |
| Synonyms | Beclin 2, BECN1L1, BECN1P1, Gm104, Gm38100, RGD1563293 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gm38100 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Apg6 coiled-coil region
- binding protein
- protein binding
- Apg6 BARA domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gm38100 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagic vacuole assembly
- autophagy
- late endosome to vacuole transport
- endosome to lysosome transport
- macromitophagy
- cellular response to nitrogen starvation
Cellular Component
Where in the cell the gene product is active
- phosphatidylinositol 3-kinase complex II
- phosphatidylinositol 3-kinase complex I
- pre-autophagosomal structure
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol 3-kinase binding
- protein binding
- protein binding, bridging