Ccl27 Gene Summary [Rat]
Predicted to enable CCR3 chemokine receptor binding activity; CXCR chemokine receptor binding activity; and chemokine activity. Predicted to be involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; cellular response to lipopolysaccharide; and neutrophil chemotaxis. Predicted to act upstream of or within regulation of actin cytoskeleton organization. Predicted to be active in extracellular space. Orthologous to human CCL27 (C-C motif chemokine ligand 27). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccl27 |
| Official Name | C-C motif chemokine ligand 27 [Source:RGD Symbol;Acc:1304660] |
| Ensembl ID | ENSRNOG00000039530 |
| Bio databases IDs | |
| Aliases | C-C motif chemokine ligand 27 |
| Synonyms | ALP, AW558992, CCL27A, CCL27B, C-C motif chemokine ligand 27, C-C motif chemokine ligand 27A, CTACK, CTAK, ESKINE, ILC, LOC545608, PESKY, SCYA27, Scya27a |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ccl27 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CCR chemokine receptor binding
- chemokine
- Small cytokines (intecrine/chemokine), interleukin-8 like
- protein binding
- cytokine
Pathways
Biological processes and signaling networks where the Ccl27 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- squamous cell cancer
- psoriasis
- pruritus
- Alzheimer disease
- skin basal cell carcinoma
- basal cell skin cancer
- squamous-cell carcinoma
- atopic dermatitis
- actinic keratosis
- sarcoidosis
regulates
- AKT
- Ca2+
- CCL18
role in cell
- growth
- migration
- apoptosis
- chemotaxis
- binding
- recruitment
- organization
- rearrangement
- reorganization
- extravasation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- perinuclear region
- Nucleus
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ccl27 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chemotaxis
- immune response
- signal transduction
- cell-cell signaling
- cell chemotaxis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- CCR3 chemokine receptor binding
- chemokine activity