Slc41a1 Gene Summary [Rat]
Predicted to enable magnesium:sodium antiporter activity. Predicted to be involved in cellular response to magnesium ion; intracellular magnesium ion homeostasis; and magnesium ion transmembrane transport. Predicted to be located in basolateral plasma membrane. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in nephronophthisis. Orthologous to human SLC41A1 (solute carrier family 41 member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc41a1 |
| Official Name | solute carrier family 41 member 1 [Source:RGD Symbol;Acc:1311397] |
| Ensembl ID | ENSRNOG00000042320 |
| Bio databases IDs | |
| Aliases | solute carrier family 41 member 1 |
| Synonyms | B230315F01Rik, MgtE, NPHPL2, solute carrier family 41 member 1, solute carrier family 41, member 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc41a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- sodium ion transporter
- antiporter
- inorganic uptake permease
- protein binding
- magnesium ion transporter
- metal ion transporter
- transporter
- Divalent cation transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease
- tinnitus
- nephronophthisis-like nephropathy type 2
- kidney disease
- allergic sensitization
regulated by
- UCP1
- monocrotaline
- magnesium
- zeaxanthin dipalmitate
- diethylstilbestrol
regulates
- magnesium
- NFATC3
- metal ion
role in cell
- function
- proliferation
- expression in
- apoptosis
- migration
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- basolateral membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc41a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- magnesium ion transport
- cellular response to magnesium ion
- sodium ion transmembrane transport
- metal ion transport
- cellular magnesium ion homeostasis
Cellular Component
Where in the cell the gene product is active
- macromolecular complex
- basolateral plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- inorganic cation transmembrane transporter activity
- protein binding
- transmembrane transporter activity
- magnesium ion transmembrane transporter activity