Slc10a1 Gene Summary [Rat]
Enables bile acid:sodium symporter activity. Involved in several processes, including bile acid and bile salt transport; response to estrogen; and response to ethanol. Located in basolateral plasma membrane. Biomarker of alcoholic hepatitis; cholestasis; and obesity. Orthologous to human SLC10A1 (solute carrier family 10 member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc10a1 |
| Official Name | solute carrier family 10 member 1 [Source:RGD Symbol;Acc:3681] |
| Ensembl ID | ENSRNOG00000005794 |
| Bio databases IDs | |
| Aliases | solute carrier family 10 member 1 |
| Synonyms | FHCA2, NTCP, Ntcp1, SBACT, sodium/bile Acid Cotransporter, Sodium dependent taurocholate cotransporting polypeptide, Sodium/Taurocholate Cotransporting Polypeptide1, solute carrier family 10 member 1, solute carrier family 10 (sodium/bile acid cotransporter family), member 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc10a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- bile acid:sodium symporter
- bile acid transporter
- protein binding
- Sodium Bile acid symporter family
- Predicted Na+-dependent transporter YfeH [General function prediction only]
- transporter
Pathways
Biological processes and signaling networks where the Slc10a1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatitis B virus-related hepatocellular carcinoma
- liver cancer
- epithelial cancer
- organismal death
- progressive familial intrahepatic cholestasis type 1
- cholestatic alcoholic hepatitis
- familial hypercholanemia type 2
- chronic hepatitis D
- cholestasis
- hepatocellular carcinoma
role in cell
- proliferation
- expression in
- transport in
- migration
- uptake in
- glycolysis in
- binding in
- upregulation in
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- intracellular space
- cellular membrane
- basolateral cell surfaces
- basolateral membrane
- sinusoidal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc10a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- sodium ion transport
- response to ethanol
- transmembrane transport
- response to estrogen stimulus
- cellular response to xenobiotic stimulus
- response to organic cyclic compound
- response to nutrient levels
- bile acid and bile salt transport
Cellular Component
Where in the cell the gene product is active
- basolateral plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- bile acid:sodium symporter activity
- protein binding
- viral receptor activity