Avpr2 Gene Summary [Rat]
Predicted to enable vasopressin receptor activity. Involved in several processes, including negative regulation of urine volume; positive regulation of systemic arterial blood pressure; and telencephalon development. Predicted to be located in endocytic vesicle; endosome; and perinuclear region of cytoplasm. Predicted to be active in plasma membrane. Used to study hypertension. Biomarker of ureteral obstruction. Human ortholog(s) of this gene implicated in X-linked nephrogenic diabetes insipidus; nephrogenic diabetes insipidus; and nephrogenic syndrome of inappropriate antidiuresis. Orthologous to human AVPR2 (arginine vasopressin receptor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Avpr2 |
| Official Name | arginine vasopressin receptor 2 [Source:RGD Symbol;Acc:2186] |
| Ensembl ID | ENSRNOG00000059862 |
| Bio databases IDs | |
| Aliases | arginine vasopressin receptor 2 |
| Synonyms | ADHR, arginine vasopressin receptor 2, DI1, DIR, DIR3, ND1, NDI, NDI1, V2R, vasopressin V2-receptor, VPV2R |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Avpr2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- intracellular loop
- signaling receptor activity
- vasopressin receptor
- transmembrane domain
- extracellular loop
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- cytosolic tail domain
- seven-transmembrane G protein-coupled receptor superfamily
- polypeptide hormone binding
Pathways
Biological processes and signaling networks where the Avpr2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- sepsis
- acute kidney injury
- liver cirrhosis
- hyponatremia
- nephrogenic diabetes insipidus type I
- congestive heart failure
- shock response
- nocturnal polyuria
- autosomal dominant polycystic kidney disease
- septic shock
role in cell
- proliferation
- osteoblastogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- endoplasmic reticulum fraction
- Golgi-enriched fraction
- membrane fraction
- endocytic vesicle membrane
- Cytoplasm
- cell surface
- intracellular space
- perinuclear region
- membrane surface
- cellular membrane
- endosomes
- Golgi Apparatus
- Endoplasmic Reticulum
- lateral cell surfaces
- basolateral cell surfaces
- acrosome
- endocytotic vesicle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Avpr2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to cytokine stimulus
- telencephalon development
- renal water retention
- G-protein coupled receptor signaling pathway
- negative regulation of cell proliferation
- positive regulation of vasoconstriction
- positive regulation of cell proliferation
- positive regulation of systemic arterial blood pressure
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
- hemostasis
- regulation of systemic arterial blood pressure by vasopressin
- positive regulation of gene expression
- cellular response to hormone stimulus
- activation of adenylate cyclase activity
Cellular Component
Where in the cell the gene product is active
- endocytic vesicle
- endosome
- perinuclear region of cytoplasm
- clathrin-coated endocytic vesicle membrane
- membrane
- endoplasmic reticulum
- Golgi apparatus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- vasopressin receptor activity
- peptide binding