Cfhr1 Gene Summary [Rat]
Predicted to enable complement component C3b binding activity and identical protein binding activity. Predicted to be involved in complement activation and cytolysis by host of symbiont cells. Predicted to be part of protein-containing complex. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in acute myeloid leukemia; age related macular degeneration 1; atypical hemolytic-uremic syndrome; and multiple myeloma. Orthologous to several human genes including CFHR1 (complement factor H related 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cfhr1 |
| Official Name | complement factor H-related 1 [Source:RGD Symbol;Acc:1310510] |
| Ensembl ID | ENSRNOG00000042901 |
| Bio databases IDs | |
| Aliases | complement factor H-related 1 |
| Synonyms | Cfhl1, Cfhr1-ps1, CFHRB, Comp fctr h-like 1, complement factor H-related 1, complement factor H-related 1, pseudogene 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cfhr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CCP
- Sushi repeat (SCR repeat)
- identical protein binding
- SUSHI repeat
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface