Trim24 Gene Summary [Rat]
Predicted to enable several functions, including estrogen response element binding activity; lysine-acetylated histone binding activity; and p53 binding activity. Involved in response to peptide hormone. Predicted to be located in cytoplasm; euchromatin; and nucleus. Predicted to be active in chromatin. Orthologous to human TRIM24 (tripartite motif containing 24). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trim24 |
| Official Name | tripartite motif-containing 24 [Source:RGD Symbol;Acc:1560596] |
| Ensembl ID | ENSRNOG00000013251 |
| Bio databases IDs | |
| Aliases | tripartite motif-containing 24 |
| Synonyms | A130082H20Rik, D430004I05Rik, hTIF1, PTC6, RNF82, TF1A, TIF1, TIF1A, TIF1ALPHA, TIF1-α, tripartite motif-containing 24 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Trim24 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- coiled-coil (CC) domain of Drosophila brain tumor (brat) and similar proteins
- PHD zinc finger
- transcription regulator
- LXXLL motif
- protein kinase
- transcription co-activator
- B-Box C-terminal domain
- chromatin binding
- Bromodomain
- zinc ion binding
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- B-box zinc finger
- histone binding
- ligand-dependent nuclear receptor interactor
- nucleic acid binding
- ubiquitin protein ligase activity
- HP1 binding domain
- p53 binding
- protein binding
- receptor binding
- sequence-specific DNA binding
- B-box-type zinc finger superfamily
- double-stranded DNA binding
- ubiquitin-protein transferase activity
- PHD finger superfamily
Pathways
Biological processes and signaling networks where the Trim24 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- epithelial neoplasia
- cancer
- liver cancer
- liver neoplasia
- digestive system cancer
- abdominal cancer
- organismal death
- ovarian cancer
role in cell
- expression in
- accumulation in
- apoptosis
- proliferation
- differentiation
- growth
- phosphorylation in
- colony formation by
- ubiquitination in
- innate immune response in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin fraction
- perichromatin fibril
- nuclear chromatin
- heterochromatin
- Cytoplasm
- cytosol
- nucleosomes
- nucleoplasm
- pronucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Trim24 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcium ion homeostasis
- protein catabolic process
- transcription from RNA polymerase II promoter
- regulation of apoptotic process
- response to peptide hormone stimulus
- cellular response to estrogen stimulus
- regulation of protein stability
- epithelial cell proliferation
- negative regulation of transcription, DNA-dependent
- regulation of vitamin D receptor signaling pathway
- positive regulation of transcription, DNA-dependent
- positive regulation of gene expression
- negative regulation of epithelial cell proliferation
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- euchromatin
- perichromatin fibrils
- mitochondrion
- cytosol
- chromatin
- nucleoplasm
- male germ cell nucleus
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- p53 binding
- ligand-dependent nuclear receptor binding
- protein binding
- transcription coactivator activity
- estrogen response element binding
- methylated histone residue binding
- histone acetyl-lysine binding
- protein kinase activity
- chromatin binding
- receptor binding