Tomm7 Gene Summary [Rat]
Predicted to be involved in positive regulation of protein targeting to mitochondrion; positive regulation of type 2 mitophagy; and regulation of protein stability. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial outer membrane translocase complex. Orthologous to human TOMM7 (translocase of outer mitochondrial membrane 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tomm7 |
| Official Name | translocase of outer mitochondrial membrane 7 [Source:RGD Symbol;Acc:1591393] |
| Ensembl ID | ENSRNOG00000043114 |
| Bio databases IDs | |
| Aliases | translocase of outer mitochondrial membrane 7 |
| Synonyms | 1110020J08RIK, AW047273, GMPGS, LOC682454, TOM7, TOMM07, translocase of outer mitochondrial membrane 7 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tomm7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein carrier
- protein binding
- TOM7 family
- transporter
Pathways
Biological processes and signaling networks where the Tomm7 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- COVID-19
- garg-mishra progeroid syndrome
- peripheral arterial disease
- metabolic syndrome X
regulates
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- Mitochondria
- mitochondrial outer membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tomm7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein targeting to mitochondrion
- protein import into mitochondrial outer membrane
- regulation of protein stability
- protein import into mitochondrial matrix
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- mitochondrial outer membrane
- mitochondrial outer membrane translocase complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein transmembrane transporter activity