Mpst Gene Summary [Rat]
Enables identical protein binding activity and thiosulfate-cyanide sulfurtransferase activity. Involved in several processes, including liver development; spinal cord development; and transsulfuration. Located in mitochondrion. Biomarker of type 2 diabetes mellitus. Orthologous to human MPST (mercaptopyruvate sulfurtransferase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mpst |
| Official Name | mercaptopyruvate sulfurtransferase [Source:RGD Symbol;Acc:620065] |
| Ensembl ID | ENSRNOG00000000185 |
| Bio databases IDs | |
| Aliases | mercaptopyruvate sulfurtransferase |
| Synonyms | 3-MST, mercaptopyruvate sulfurtransferase, mercaptopyruvate sulphurtransferase, MST, TST2, TUM1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mpst often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rhodanese Homology Domain
- 3-mercaptopyruvate sulfurtransferase
- enzyme
- thiosulfate sulfurtransferase
- protein binding
- Rhodanese-like domain
- identical protein binding
- RHOD
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bipolar disorder
role in cell
- stimulation
- stimulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
- mitochondrial matrix
- neurites
- photoreceptor outer segments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mpst gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sulfur amino acid catabolic process
- hydrogen sulfide biosynthetic process
- kidney development
- liver development
- cyanate catabolic process
- transsulfuration
- response to toxin
- spinal cord development
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- mitochondrial matrix
- mitochondrion
- synapse
- neuron projection
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- thiosulfate sulfurtransferase activity
- 3-mercaptopyruvate sulfurtransferase activity