Cd34 Gene Summary [Rat]
Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity; carbohydrate binding activity; and sulfate binding activity. Involved in glomerular filtration and mesangial cell-matrix adhesion. Located in apical plasma membrane; basal plasma membrane; and lysosome. Part of glomerular endothelium fenestra. Biomarker of diabetic retinopathy. Orthologous to human CD34 (CD34 molecule). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cd34 |
| Official Name | CD34 molecule [Source:RGD Symbol;Acc:1306863] |
| Ensembl ID | ENSRNOG00000045558 |
| Bio databases IDs | |
| Aliases | CD34 molecule |
| Synonyms | CD34 ANTIGEN, CD34 molecule, LOC100911324, MESENCHYMAL STEM CELL ANTIGEN |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cd34 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CD34/Podocalyxin family
- binding protein
- intracellular domain
- transcription factor binding
- protein binding
- carbohydrate binding
Pathways
Biological processes and signaling networks where the Cd34 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastrointestinal stromal tumor
- neoplasia
- uterine leiomyoma
- leiomyomatosis
- breast carcinoma
- early precursor T-cell acute lymphoblastic leukemia
- papillomatosis
- epithelial neoplasia
- benign neoplasia
- Alzheimer disease
role in cell
- migration
- number
- proliferation
- growth
- adhesion
- binding
- hematopoiesis
- abnormal morphology
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- Extracellular Space
- cell periphery
- perinuclear region
- cellular membrane
- lysosome
- cytoplasmic bridges
- plasma membrane extracellular face
- apical membrane
- basal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cd34 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glomerular filtration
- hemopoiesis
- positive regulation of angiogenesis
- endothelium development
- negative regulation of interleukin-2 production
- extracellular vesicular exosome assembly
- positive regulation of odontogenesis
- stem cell proliferation
- transdifferentiation
- mesangial cell-matrix adhesion
- positive regulation of granulocyte colony-stimulating factor production
- cell-matrix adhesion
- signal transduction
- vascular wound healing
- paracrine signaling
- glomerular endothelium development
- tissue homeostasis
- cell motility
- negative regulation of gene expression
- positive regulation of gene expression
- metanephric glomerular mesangial cell differentiation
- endothelial cell proliferation
- positive regulation of vasculogenesis
- hemopoietic stem cell proliferation
- leukocyte migration
Cellular Component
Where in the cell the gene product is active
- basal plasma membrane
- intercellular bridge
- perinuclear region of cytoplasm
- cytoplasm
- glomerular endothelium fenestra
- external side of plasma membrane
- extracellular region
- apical plasma membrane
- plasma membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- sulfate binding
- carbohydrate binding