Sell Gene Summary [Rat]
Enables glycolipid binding activity. Involved in several processes, including cellular response to interleukin-8; positive regulation of neutrophil chemotaxis; and regulation of leukocyte adhesion to vascular endothelial cell. Located in cell surface and extracellular space. Used to study colitis; hepatitis; peripheral vascular disease; and ureteral obstruction. Biomarker of abdominal aortic aneurysm; alcoholic hepatitis; endometriosis; pancreatitis; and toxic shock syndrome. Human ortholog(s) of this gene implicated in Crohn's disease; IgA glomerulonephritis; and ulcerative colitis. Orthologous to human SELL (selectin L). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sell |
| Official Name | selectin L [Source:RGD Symbol;Acc:3655] |
| Ensembl ID | ENSRNOG00000002776 |
| Bio databases IDs | |
| Aliases | selectin L |
| Synonyms | A.11, CD62L, LAM-1, LECAM-1, LEU8, LNHR, LSEL, L-selectin, Ly-22, LYAM1, Ly-m22, lymphocyte adhesion molecule 1, PLNHR, selectin L, selectin, lymphocyte, TQ1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sell often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cell adhesion molecule binding
- carbohydrate recognition domain
- consensus repeat domain
- EGF_CA
- cytoplasmic domain
- carbohydrate binding
- membrane-proximal domain
- transmembrane receptor
- SUSHI repeat
- lectin domain
- extracellular domain
- sphingolipid binding
- lipid binding
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- protease binding
- ectodomain
- Human growth factor-like EGF
- calcium ion binding
- protein binding
- EGF-like domain
- CCP
- binding protein
- transmembrane domain
- Lectin C-type domain
- cytosolic tail domain
- heparin binding
Pathways
Biological processes and signaling networks where the Sell gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- mycosis fungoides
- neoplasia
- breast cancer
- neutrophilia
- fibrosis
- delayed hypersensitive reaction
- edema
- Crohn disease
- non-insulin-dependent diabetes mellitus
role in cell
- function
- activation
- apoptosis
- migration
- activation in
- proliferation
- depletion
- chemotaxis
- binding
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell-associated matrix
- cell surface
- cell borders
- Extracellular Space
- membrane surface
- cellular membrane
- secretory granule membrane
- plasma membrane extracellular face
- membrane rafts
- microvilli
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sell gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to cytokine stimulus
- calcium-dependent cell-cell adhesion
- heterophilic cell-cell adhesion
- cell adhesion
- leukocyte tethering or rolling
- leukocyte cell-cell adhesion
Cellular Component
Where in the cell the gene product is active
- secretory granule membrane
- extracellular space
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- oligosaccharide binding
- glycosphingolipid binding
- protein binding
- calcium ion binding
- sialic acid binding
- heparin binding
- protease binding
- carbohydrate binding