Star Gene Summary [Rat]
Predicted to enable cholesterol binding activity. Involved in several processes, including cellular response to peptide hormone stimulus; response to glucocorticoid; and steroid metabolic process. Located in mitochondrial crista and neuronal cell body. Biomarker of hypogonadism; hypothyroidism; nephrosis; polycystic ovary syndrome; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia. Orthologous to human STAR (steroidogenic acute regulatory protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Star |
| Official Name | steroidogenic acute regulatory protein [Source:RGD Symbol;Acc:3770] |
| Ensembl ID | ENSRNOG00000015052 |
| Bio databases IDs | |
| Aliases | steroidogenic acute regulatory protein |
| Synonyms | D8Ertd419e, STARD1, steroidogenic acute regulatory protein |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Star often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SRPBCC domain
- lipid transporter
- mitochondrial presequence
- cholesterol binding
- protein binding
- transporter
Pathways
Biological processes and signaling networks where the Star gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- congenital lipoid adrenal hyperplasia
- Alzheimer disease
- growth failure
- adrenal cortex carcinoma
- adrenocortical carcinoma
- orthostatic hypotension
- hypoplasia
- adrenal cortical hyperplasia
- endometriosis
role in cell
- activation in
- apoptosis
- cell death
- expression in
- binding in
- quantity
- mitochondrial respiration in
- production in
- morphology
- transmembrane potential
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- mitochondrial fraction
- somatodendritic region
- Nucleus
- Mitochondria
- lipid droplets
- mitochondria-associated membranes
- mitochondrial cristae
- mitochondrial matrix
- mitochondrial intermembrane space
- mitochondrial outer membrane
- mitochondrial inner membrane
- extracellular matrix
- perikaryon
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Star gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of bile acid biosynthetic process
- cholesterol metabolic process
- intracellular cholesterol transport
- cellular lipid metabolic process
- glucocorticoid metabolic process
- steroid biosynthetic process
- regulation of steroid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial intermembrane space
- mitochondrial matrix
Molecular Function
What the gene product does at the molecular level
- protein binding
- cholesterol binding