Adgre1 Gene Summary [Rat]
Predicted to enable G protein-coupled receptor activity. Involved in cellular response to transforming growth factor beta stimulus and cellular response to tumor necrosis factor. Predicted to be located in external side of plasma membrane. Predicted to be active in plasma membrane. Orthologous to human ADGRE1 (adhesion G protein-coupled receptor E1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adgre1 |
| Official Name | adhesion G protein-coupled receptor E1 [Source:RGD Symbol;Acc:1359214] |
| Ensembl ID | ENSRNOG00000046254 |
| Bio databases IDs | |
| Aliases | adhesion G protein-coupled receptor E1 |
| Synonyms | adhesion G protein-coupled receptor E1, DD7A5-7, EGF-TM7, EMR1, F4/80, Gpf480, Ly71, TM7LN3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Adgre1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- 7 transmembrane receptor (Secretin family)
- Protein of unknown function (DUF2975)
- EGF domain
- GPCR proteolysis site, GPS, motif
- seven-transmembrane G protein-coupled receptor superfamily
- EGF_CA
Pathways
Biological processes and signaling networks where the Adgre1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cell periphery
- cellular membrane
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Adgre1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- adaptive immune response
- cell adhesion
- cell surface receptor signaling pathway
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- calcium ion binding