Sh3rf3 Gene Summary [Rat]
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in positive regulation of JNK cascade; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; and protein autoubiquitination. Orthologous to human SH3RF3 (SH3 domain containing ring finger 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sh3rf3 |
| Official Name | SH3 domain containing ring finger 3 [Source:RGD Symbol;Acc:1589772] |
| Ensembl ID | ENSRNOG00000046791 |
| Bio databases IDs | |
| Aliases | SH3 domain containing ring finger 3 |
| Synonyms | 4831416G18Rik, Hypothetical Src Homology 3 Domain, Igfbp5-ip, POSH2, SH3 domain containing ring finger 3, SH3MD4, Sh3rf31 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sh3rf3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Family of unknown function (DUF5585)
- RING-type zinc-finger
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- enzyme
- Ring finger domain
- protein binding
- RING-like zinc finger
- Src Homology 3 domain superfamily
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sh3rf3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of JNK cascade
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- protein ubiquitination
- protein autoubiquitination
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding