Tanc2 Gene Summary [Rat]
A structural constituent of postsynaptic density. Involved in dense core granule cytoskeletal transport; regulation of dendritic spine development; and regulation of dendritic spine morphogenesis. Located in dendritic spine. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Human ortholog(s) of this gene implicated in intellectual developmental disorder with autistic features and language delay, with or without seizures. Orthologous to human TANC2 (tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tanc2 |
| Official Name | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 [Source:RGD Symbol;Acc:1309285] |
| Ensembl ID | ENSRNOG00000052840 |
| Bio databases IDs | |
| Aliases | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 |
| Synonyms | 3526402J09RIK, 5730590C14Rik, IDDALDS, RGD1309285, rols, ROLSA, tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tanc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Ankyrin repeats (many copies)
- Tetratricopeptide repeats
- Ankyrin repeats (3 copies)
- protein binding
- structural molecule
- tetratricopeptide repeat
- Ankyrin repeat
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- prostate cancer
- cleft lip
- pervasive developmental disorder
- developmental delay
- hereditary disorder
- intellectual developmental disorder with autistic features and language delay without seizures
- intellectual developmental disorder with autistic features and language delay with or without seizures
- prostatic carcinoma
- mental retardation
role in cell
- development
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- glutaminergic synapse
- organelle
- dendritic spines
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tanc2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of dendritic spine morphogenesis
- regulation of dendritic spine development
Cellular Component
Where in the cell the gene product is active
- dendritic spine
- axon