Pot1b Gene Summary [Rat]
Predicted to enable G-rich strand telomeric DNA binding activity and telomerase inhibitor activity. Predicted to be involved in regulation of telomere maintenance via telomerase and telomere capping. Predicted to be part of nuclear telomere cap complex. Human ortholog(s) of this gene implicated in colorectal cancer; familial melanoma; hepatocellular carcinoma; lung cancer; and ovarian cancer. Orthologous to human POT1 (protection of telomeres 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pot1b |
| Official Name | protection of telomeres 1B [Source:RGD Symbol;Acc:1582873] |
| Ensembl ID | ENSRNOG00000047439 |
| Bio databases IDs | |
| Aliases | protection of telomeres 1B |
| Synonyms | 2810458H16Rik, AC182748.1, LOC681796, protection of telomeres 1B |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pot1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- damaged DNA binding
- single-stranded DNA binding
- DEAD/H-box RNA helicase binding
- enzyme inhibitor activity
- DNA secondary structure binding
- enzyme binding
- protein binding
- sequence-specific DNA binding
- telomeric DNA binding
- oligonucleotide/oligosaccharide-binding fold of replication protein A and class 2b aminoacyl-tRNA synthetases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- telomeres