Ctc1 Gene Summary [Rat]
Predicted to enable G-rich strand telomeric DNA binding activity. Predicted to be involved in negative regulation of telomere maintenance via telomerase; positive regulation of DNA replication; and telomere maintenance via telomere lengthening. Predicted to act upstream of or within several processes, including hematopoietic or lymphoid organ development; hematopoietic stem cell proliferation; and replicative senescence. Predicted to be located in chromosome, telomeric region; cytosol; and nucleoplasm. Predicted to be part of CST complex. Orthologous to human CTC1 (CST telomere replication complex component 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ctc1 |
| Official Name | CST telomere replication complex component 1 [Source:RGD Symbol;Acc:1563106] |
| Ensembl ID | ENSRNOG00000005357 |
| Bio databases IDs | |
| Aliases | CST telomere replication complex component 1 |
| Synonyms | 1500010J02Rik, AAF-132, C17orf68, CRMCC, CST telomere replication complex component 1, CTS telomere maintenance complex component 1, FLJ22170, RGD1563106, tmp494178 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ctc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CST, telomere maintenance, complex subunit CTC1
- single-stranded DNA binding
- protein binding
- sequence-specific DNA binding
- telomeric DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dyskeratosis congenita
- hereditary disorder
- Parkinson disease
- cerebroretinal microangiopathy with calcifications and cysts 1
- tinnitus
- chromosomal instability
- cerebroretinal microangiopathy with calcifications and cysts
role in cell
- proliferation
- accumulation in
- binding in
- number
- length
- formation
- formation in
- replication
- replication in
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- telomeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ctc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organism growth
- replicative senescence
- telomere maintenance
- spleen development
- positive regulation of DNA replication
- response to DNA damage stimulus
- bone marrow development
- thymus development
- positive regulation of fibroblast proliferation
- hemopoietic stem cell proliferation
- telomere maintenance via telomere lengthening
- negative regulation of telomere maintenance via telomerase
- telomere capping
- regulation of G2/M transition of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- nucleus
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- telomeric DNA binding
- single-stranded DNA binding