Acd Gene Summary [Rat]
Predicted to enable DNA polymerase binding activity; telomerase inhibitor activity; and telomeric DNA binding activity. Predicted to be involved in several processes, including establishment of protein localization; negative regulation of telomere maintenance via telomerase; and telomere organization. Predicted to act upstream of or within several processes, including embryonic limb morphogenesis; telomere maintenance; and urogenital system development. Predicted to be located in chromosome, telomeric region and nuclear body. Predicted to be part of shelterin complex. Human ortholog(s) of this gene implicated in autosomal dominant dyskeratosis congenita 6. Orthologous to human ACD (ACD shelterin complex subunit and telomerase recruitment factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Acd |
| Official Name | ACD, shelterin complex subunit and telomerase recruitment factor [Source:RGD Symbol;Acc:1565053] |
| Ensembl ID | ENSRNOG00000038973 |
| Bio databases IDs | |
| Aliases | ACD, shelterin complex subunit and telomerase recruitment factor |
| Synonyms | ACD shelterin complex subunit and telomerase recruitment factor, ACD, shelterin complex subunit and telomerase recruitment factor, adrenocortical dysplasia, PIP1, PTOP, TINT1, TPP1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Acd often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- proline-tryptophan-isoleucine motif
- nuclear export signal
- serine-rich region
- binding protein
- enzyme inhibitor activity
- enzyme binding
- oligosaccharide/oligonucleotide-binding fold
- protein binding
- POT1 recruitment domain
- Shelterin complex subunit, TPP1/ACD
- telomeric DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal dominant dyskeratosis congenita type 6
- chronic lymphocytic leukemia
- long telomere syndrome
- autosomal recessive dyskeratosis congenita type 7
- ACD-related short telomere syndrome
role in cell
- apoptosis
- binding in
- proliferation
- growth
- elongation
- maintenance
- length
- DNA damage response
- maintenance in
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- nucleoplasm
- nuclear bodies
- telomeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Acd gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- segmentation
- positive regulation of single-stranded telomeric DNA binding
- telomere maintenance via telomerase
- telomere maintenance
- intracellular protein transport
- positive regulation of telomerase activity
- embryonic limb morphogenesis
- skeletal system development
- urogenital system development
- establishment of protein localization to telomere
- protection from non-homologous end joining at telomere
- protein localization to chromosome, telomeric region
- positive regulation of telomere maintenance via telomerase
- telomere assembly
- negative regulation of telomere maintenance via telomerase
- telomere capping
- positive regulation of telomere maintenance
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- nuclear body
- telosome
- telomerase holoenzyme complex
- nucleoplasm
- nuclear telomere cap complex
Molecular Function
What the gene product does at the molecular level
- DNA polymerase binding
- protein binding
- telomeric DNA binding