Gas7 Gene Summary [Rat]
Predicted to enable actin filament binding activity and identical protein binding activity. Predicted to be involved in clathrin coat assembly; clathrin-dependent endocytosis; and neuron projection morphogenesis. Predicted to act upstream of or within actin filament organization; neuron differentiation; and regulation of cell shape. Predicted to be located in actin filament and ruffle. Predicted to be active in clathrin-coated pit; clathrin-coated vesicle; and plasma membrane. Orthologous to human GAS7 (growth arrest specific 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gas7 |
| Official Name | growth arrest specific 7 [Source:RGD Symbol;Acc:621550] |
| Ensembl ID | ENSRNOG00000049361 |
| Bio databases IDs | |
| Aliases | growth arrest specific 7 |
| Synonyms | B230343A10RIK, Gas7-cb, growth arrest specific 7, Growth arrest specific mRNA clone 3544 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gas7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- PspA/IM30 family
- Unstructured linker region between on GAS7 protein
- WW class I binding domain
- Fes/CIP4, and EFC/F-BAR homology domain
- protein binding
- Bin/Amphiphysin/Rvs domain
- identical protein binding
- Src Homology 3 domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- proteinuria
- Alzheimer disease
- glaucoma
- open-angle glaucoma
- metastasis
- schizophrenia
- sensory neuropathy
- chronic kidney disease
- jaundice
role in cell
- apoptosis
- phosphorylation in
- binding in
- expression in
- formation in
- outgrowth
- differentiation
- formation
- maturation
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ruffle
- Mitochondria
- actin filaments
- plasma membrane projections
- growth cone
- neurites
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gas7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- actin filament polymerization
- neuron projection morphogenesis
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- actin filament
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding