Gas7 Gene Summary [Mouse]
Enables actin filament binding activity. Acts upstream of or within actin filament organization; neuron projection morphogenesis; and regulation of cell shape. Located in actin filament and ruffle. Is expressed in forebrain. Orthologous to human GAS7 (growth arrest specific 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gas7 |
| Official Name | growth arrest specific 7 [Source:MGI Symbol;Acc:MGI:1202388] |
| Ensembl ID | ENSMUSG00000033066 |
| Bio databases IDs | |
| Aliases | growth arrest specific 7 |
| Synonyms | B230343A10RIK, Gas7-cb, growth arrest specific 7, Growth arrest specific mRNA clone 3544 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gas7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- PspA/IM30 family
- Unstructured linker region between on GAS7 protein
- WW class I binding domain
- Fes/CIP4, and EFC/F-BAR homology domain
- protein binding
- Bin/Amphiphysin/Rvs domain
- identical protein binding
- Src Homology 3 domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- proteinuria
- Alzheimer disease
- glaucoma
- open-angle glaucoma
- metastasis
- schizophrenia
- sensory neuropathy
- chronic kidney disease
- jaundice
role in cell
- apoptosis
- phosphorylation in
- binding in
- expression in
- formation in
- outgrowth
- differentiation
- formation
- maturation
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ruffle
- Mitochondria
- actin filaments
- plasma membrane projections
- growth cone
- neurites
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gas7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- actin filament polymerization
- neuron projection morphogenesis
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- actin filament
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding