Usp34 Gene Summary [Rat]
Predicted to enable cysteine-type deubiquitinase activity and cysteine-type endopeptidase activity. Predicted to be involved in positive regulation of canonical Wnt signaling pathway; protein K48-linked deubiquitination; and regulation of protein stability. Predicted to be active in cytosol and nucleus. Orthologous to human USP34 (ubiquitin specific peptidase 34). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Usp34 |
| Official Name | ubiquitin specific peptidase 34 [Source:RGD Symbol;Acc:1565181] |
| Ensembl ID | ENSRNOG00000051889 |
| Bio databases IDs | |
| Aliases | ubiquitin specific peptidase 34 |
| Synonyms | A530081C03RIK, MURR2, ubiquitin specific peptidase 34 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Usp34 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain of unknown function (DUF3517)
- cysteine endopeptidase
- peptidase
- Ubiquitin carboxyl-terminal hydrolase
- ubiquitin-specific protease
- protein binding
- Peptidase_C19
Pathways
Biological processes and signaling networks where the Usp34 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- cardiovascular disorder
- hypothyroidism
- Crohn disease
- adenoid cystic carcinoma of salivary gland
- salivary gland cancer
- atrial fibrillation
- congenital heart disease
- Brugada syndrome
- stuttering
regulates
- p38 MAPK
- AXIN1
role in cell
- degradation in
- phosphorylation in
- 5-fluorouracil resistance
- cisplatin sensitivity
- methyl methanesulfonate sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Usp34 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deubiquitination
- proteolysis
- positive regulation of canonical Wnt receptor signaling pathway
- Wnt receptor signaling pathway
- protein K48-linked deubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- protein binding
- cysteine-type endopeptidase activity